USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: DESM_HUMAN USC-OGP 2-DE database:  DESM_HUMAN DESM_HUMAN General information about the entry View entry in simple text format Entry name DESM_HUMAN Primary accession number P17661 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Desmin;. Gene name Name=DES Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1161: pI=5.44; Mw=49904 SPOT OGP-1171: pI=4.97; Mw=46576 SPOT OGP-1179: pI=5.29; Mw=44651 SPOT OGP-1180: pI=4.73; Mw=44526 SPOT OGP-1181: pI=5.40; Mw=44276 Cross-references UniProtKB/Swiss-Prot P17661; DESM_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name DESM_HUMAN Primary accession number P17661 Secondary accession number(s) Q15787 Q549R7 Q549R8 Q549R9 Q8IZR1 Q8IZR6 Q8NES2 Q8NEU6 Q8TAC4 Q8TCX2 Q8TD99 Q9UHN5 Q9UJ80 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 185) Name and origin of the protein Description RecName: Full=Desmin; Gene name Name=DES Encoded on Name=DES Keywords ADP-ribosylation; Cardiomyopathy; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Desmin-related myopathy; Disease mutation; Intermediate filament; Limb-girdle muscular dystrophy; Membrane; Methylation; Muscle protein; Myofibrillar myopathy; Phosphoprotein; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M63391; AAA99221.1; -; Genomic_DNA EMBL U59167; AAC50680.1; -; mRNA EMBL AF055081; AAC39938.1; -; mRNA EMBL AF055082; AAC39939.1; -; mRNA EMBL AF055083; AAC39940.1; -; mRNA EMBL AF137053; AAF15400.1; -; mRNA EMBL AF486807; AAL93205.1; -; mRNA EMBL AF487828; AAL99078.1; -; mRNA EMBL AF521879; AAN15036.1; -; mRNA EMBL AF527578; AAN37810.1; -; mRNA EMBL AY083345; AAL99215.1; -; mRNA EMBL AY114212; AAM47026.1; -; Genomic_DNA EMBL AY125465; AAM95238.1; -; mRNA EMBL BC032116; AAH32116.1; -; mRNA EMBL AJ132926; CAB62389.1; -; mRNA CCDS CCDS33383.1; -; . PIR JE0063; DMHU; . RefSeq NP_001918.3; NM_001927.3; . UniGene Hs.594952; -; . ProteinModelPortal P17661; -; . SMR P17661; -; . BioGrid 108038; 39; . IntAct P17661; 52; . MINT MINT-215829; -; . STRING 9606.ENSP00000363071; -; . iPTMnet P17661; -; . PhosphoSitePlus P17661; -; . SwissPalm P17661; -; . BioMuta DES; -; . DMDM 6686280; -; . REPRODUCTION-2DPAGE IPI00465084; -; . REPRODUCTION-2DPAGE P17661; -; . SWISS-2DPAGE P17661; -; . UCD-2DPAGE P17661; -; . EPD P17661; -; . PaxDb P17661; -; . PeptideAtlas P17661; -; . PRIDE P17661; -; . DNASU 1674; -; . Ensembl ENST00000373960; ENSP00000363071; ENSG00000175084; . GeneID 1674; -; . KEGG hsa:1674; -; . CTD 1674; -; . DisGeNET 1674; -; . GeneCards DES; -; . GeneReviews DES; -; . HGNC HGNC:2770; DES; . HPA CAB000034; -; . HPA HPA018803; -; . MalaCards DES; -; . MIM 125660; gene; . MIM 181400; phenotype; . MIM 601419; phenotype; . MIM 604765; phenotype; . MIM 615325; phenotype; . neXtProt NX_P17661; -; . OpenTargets ENSG00000175084; -; . Orphanet 34517; Autosomal dominant limb-girdle muscular dystrophy type 1E; . Orphanet 363543; Autosomal recessive limb-girdle muscular dystrophy due to desmin deficiency; . Orphanet 98909; Desminopathy; . Orphanet 154; Familial isolated dilated cardiomyopathy; . Orphanet 85146; Scapuloperoneal amyotrophy; . PharmGKB PA27253; -; . eggNOG ENOG410IFZ1; Eukaryota; . eggNOG ENOG410XRBS; LUCA; . GeneTree ENSGT00830000128228; -; . HOVERGEN HBG013015; -; . InParanoid P17661; -; . KO K07610; -; . OMA HIHTHAG; -; . OrthoDB EOG091G12MK; -; . PhylomeDB P17661; -; . TreeFam TF330122; -; . Reactome R-HSA-390522; Striated Muscle Contraction; . SIGNOR P17661; -; . ChiTaRS DES; human; . GeneWiki Desmin; -; . GenomeRNAi 1674; -; . PRO PR:P17661; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000175084; -; . ExpressionAtlas P17661; baseline and differential; . Genevisible P17661; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005916; C:fascia adherens; IEA:Ensembl; . GO GO:0014704; C:intercalated disc; IDA:UniProtKB; . GO GO:0005882; C:intermediate filament; TAS:ProtInc; . GO GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA; . GO GO:0031594; C:neuromuscular junction; IEA:Ensembl; . GO GO:0042383; C:sarcolemma; IDA:UniProtKB; . GO GO:0030018; C:Z disc; IDA:UniProtKB; . GO GO:0008092; F:cytoskeletal protein binding; IPI:BHF-UCL; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc; . GO GO:0007010; P:cytoskeleton organization; TAS:ProtInc; . GO GO:0045109; P:intermediate filament organization; IMP:UniProtKB; . GO GO:0006936; P:muscle contraction; TAS:ProtInc; . GO GO:0030049; P:muscle filament sliding; TAS:Reactome; . GO GO:0008016; P:regulation of heart contraction; TAS:ProtInc; . InterPro IPR027698; DES; . InterPro IPR001664; IF; . InterPro IPR006821; Intermed_filament_DNA-bd; . InterPro IPR018039; Intermediate_filament_CS; . PANTHER PTHR23239; PTHR23239; 1; . PANTHER PTHR23239:SF307; PTHR23239:SF307; 1; . Pfam PF00038; Filament; 1; . Pfam PF04732; Filament_head; 1; . SMART SM01391; Filament; 1; . PROSITE PS00226; IF; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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